![]() ![]() Thus, in addition to some common neuronal pro-survival signaling, different types of neurons possess a variety of 'neuron type-specific' pro-survival constituents that might help them to adapt for survival in a certain brain region. ![]() Furthermore, pro-survival factors and intracellular responses depend on the type of neuron and region of the brain. To accommodate this signaling, immature neurons in the brain express a number of transmembrane factors as well as intracellular signaling molecules that will regulate the cell survival/death decision, and many of these factors cease being expressed upon neuronal maturation. External signals from brain microenvironment together with intrinsic signaling pathways determine whether a particular neuron will die. Removal of substantial numbers of neurons that are not yet completely integrated into the local circuits helps to ensure that maturation and homeostatic function of neuronal networks in the brain proceed correctly. Developmental cell death affects both embryonically produced immature neurons and those immature neurons that are generated in regions of adult neurogenesis. Neurogenic regions of mammalian brain produce many more neurons that will eventually survive and reach a mature stage. ![]()
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